Affiliation:
1. Department of Dermatology, Zhongshan Hospital Fudan University, Shanghai, China
2. The Second Clinical Medical College, Yangtze University, Jingzhou, China
Abstract
ABSTRACT
In vitro
interactions of tacrolimus, a calcineurin inhibitor, and azoles, including itraconazole, voriconazole, and posaconazole, against planktonic cells and biofilms of
Exophiala dermatitidis
were assessed via a broth microdilution checkerboard technique. A total of 16 clinical isolates were studied. The results revealed favorable synergistic inhibitory activity between tacrolimus and itraconazole, voriconazole, or posaconazole against 68.8%, 87.5%, and 100% of tested strains of planktonic
E. dermatitidis
, respectively.However, limited synergism was observed against biofilms of
E. dermatitidis
. No antagonism was observed in all combinations.
Funder
National Natural Science Foundation of China
Hubei Provincial Population and Family Planning Commission
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
9 articles.
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