Small-Molecule Inhibitor of Flaviviral NS3-NS5 Interaction with Broad-Spectrum Activity and Efficacy <i>In Vivo</i>-Reference-Cited by-同舟云学术

Small-Molecule Inhibitor of Flaviviral NS3-NS5 Interaction with Broad-Spectrum Activity and Efficacy In Vivo

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Celegato Marta¹,Sturlese Mattia²,Vasconcelos Costa Vivian³,Trevisan Marta¹,Lallo Dias Angélica Samer⁴,Souza Passos Ingredy Beatriz³,Queiroz-Junior Celso Martins³,Messa Lorenzo¹,Favaro Annagiulia²,Moro Stefano²,Teixeira Mauro Martins⁴,Loregian Arianna¹^ORCID,Mercorelli Beatrice¹^ORCID

Affiliation:

1. Department of Molecular Medicine, University of Padua, Padua, Italy

2. Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy

3. Departamento de Morfologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

4. Departamento de Bioquímica e Imunologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

Abstract

More than one-third of the human population is at risk of infection by different mosquito-borne flaviviruses. Despite this, no specific antiviral drug is currently available.

Funder

University of Padua

INCT dengue MCT/CN

EU Funding within the MUR PNRR Extended Partnership Initiative on Emerging Infectious Diseases

Associazione Italiana per la Ricerca sul Cancro

Fondazione Cassa di Risparmio di Padova e Rovigo

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03097-22

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