Repurposing Tamoxifen as Potential Host-Directed Therapeutic for Tuberculosis-Reference-Cited by-同舟云学术

Repurposing Tamoxifen as Potential Host-Directed Therapeutic for Tuberculosis

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Boland Ralf¹^ORCID,Heemskerk Matthias T.²^ORCID,Forn-Cuní Gabriel¹^ORCID,Korbee Cornelis J.²^ORCID,Walburg Kimberley V.²,Esselink Jeroen J.²,Carvalho dos Santos Carina²³,de Waal Amy M.¹,van der Hoeven Daniel C. M.¹,van der Sar Elisa¹,de Ries Alex S.¹,Xie Jiajun¹,Spaink Herman P.¹^ORCID,van der Vaart Michiel¹^ORCID,Haks Mariëlle C.²^ORCID,Meijer Annemarie H.¹^ORCID,Ottenhoff Tom H. M.²^ORCID

Affiliation:

1. Institute of Biology Leiden, Leiden University, Leiden, The Netherlands

2. Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

3. Laboratório Especial de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo, Brazil

Abstract

Tuberculosis (TB) is the world's most lethal infectious disease caused by a bacterial pathogen, Mycobacterium tuberculosis . This pathogen evades the immune defenses of its host and grows intracellularly in immune cells, particularly inside macrophages.

Funder

FASESP

Chinese Scholarship Council

European Commission

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

ZonMw

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03024-22