The Glycan-Binding Trait of the Sarbecovirus Spike N-Terminal Domain Reveals an Evolutionary Footprint-Reference-Cited by-同舟云学术

The Glycan-Binding Trait of the Sarbecovirus Spike N-Terminal Domain Reveals an Evolutionary Footprint

Published:2022-08-10 Issue:15 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Guo Hua¹,Li Ang¹²,Lin Hao-Feng¹²,Liu Mei-Qin¹²,Chen Jing¹,Jiang Ting-Ting¹,Li Bei¹,Wang Yi¹,Letko Michael C.³,Peng Wenjie⁴,Shi Zheng-Li¹^ORCID

Affiliation:

1. CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

2. University of Chinese Academy of Sciences, Beijing, China

3. Paul G. Allen School for Global Health, Washington State University, Pullman, Washington, USA

4. Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China

Abstract

Spike N-terminal domains (S-NTD) of sarbecoviruses are highly diverse; however, their function remains largely understudied compared with the receptor-binding domains (RBD). Here, we show that sarbecovirus S-NTD can be phylogenetically clustered into five clades and exhibit various levels of glycan binding in vitro .

Funder

Strategic priority research program of Chinese Academy of Science

China Natural National Foundation

National Science Foundation of China

Shanghai Pilot Program for Basic Research-Shanghai Jiao Tong University

CAS | Chinese Academy of Sciences Key Project

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00958-22