Human Nasal and Lung Tissues Infected Ex Vivo with SARS-CoV-2 Provide Insights into Differential Tissue-Specific and Virus-Specific Innate Immune Responses in the Upper and Lower Respiratory Tract-Reference-Cited by-同舟云学术

Human Nasal and Lung Tissues Infected Ex Vivo with SARS-CoV-2 Provide Insights into Differential Tissue-Specific and Virus-Specific Innate Immune Responses in the Upper and Lower Respiratory Tract

Published:2021-06-24 Issue:14 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Alfi Or¹²³,Yakirevitch Arkadi⁴⁵,Wald Ori⁶,Wandel Ori¹,Izhar Uzi⁶,Oiknine-Djian Esther¹,Nevo Yuval⁷,Elgavish Sharona⁷,Dagan Elad⁴⁵,Madgar Ory⁴⁵,Feinmesser Gilad⁴⁵,Pikarsky Eli³,Bronstein Michal⁸,Vorontsov Olesya¹²³,Jonas Wayne⁹,Ives John⁹,Walter Joan⁹,Zakay-Rones Zichria²,Oberbaum Menachem¹⁰,Panet Amos²,Wolf Dana G.¹³^ORCID

Affiliation:

1. Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel

2. Department of Biochemistry, IMRIC, The Hebrew University Faculty of Medicine, Jerusalem, Israel

3. Lautenberg Center for General and Tumor Immunology, The Hebrew University Faculty of Medicine, Jerusalem, Israel

4. Department of Otolaryngology—Head and Neck Surgery, Sheba Medical Center, Tel Hashomer, Israel

5. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

6. Department of Cardiothoracic Surgery, Hadassah University Hospital, Jerusalem, Israel

7. Bioinformatics Unit of the I-CORE Computation Center, The Hebrew University and Hadassah Hebrew University Medical Center, Jerusalem, Israel

8. Center for Genomic Technologies, Alexander Silberman Institute of Life Sciences, Hebrew University, Jerusalem, Israel

9. Samueli Institute, Alexandria, Virginia, USA

10. The Center for Integrative Complementary Medicine, Shaare Zedek Medical Center, Jerusalem, Israel

Abstract

In order to reduce the late-phase morbidity and mortality of COVID-19, there is a need to better understand and target the earliest stages of SARS-CoV-2 infection in the human respiratory tract. Here, we have studied the initial steps of SARS-CoV-2 infection and the consequent innate immune responses within the natural multicellular complexity of human nasal mucosal and lung tissues.

Funder

Israeli Ministry of Science & Technology

7th Framework Program ERA-NET

Israeli Science Ministry

Israel Science Foundation

Rothschild Foundation Hanadiv Europe (Rothschild Foundation

Samueli Institute

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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