The Pseudomonas aeruginosa Type III Secretion System Exoenzyme Effector ExoU Induces Mitochondrial Damage in a Murine Bone Marrow-Derived Macrophage Infection Model-Reference-Cited by-同舟云学术

The Pseudomonas aeruginosa Type III Secretion System Exoenzyme Effector ExoU Induces Mitochondrial Damage in a Murine Bone Marrow-Derived Macrophage Infection Model

Published:2022-03-17 Issue:3 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Hardy Kierra S.¹²,Tuckey Amanda N.¹²,Housley Nicole A.¹²,Andrews Joel³,Patel Mita⁴,Al-Mehdi Abu-Bakr⁴,Barrington Robert A.¹²,Cassel Suzanne L.⁵,Sutterwala Fayyaz S.⁵,Audia Jonathon P.¹²^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama, USA

2. Center for Lung Biology, University of South Alabama College of Medicine, Mobile, Alabama, USA

3. Mitchell Cancer Institute, University of South Alabama College of Medicine, Mobile, Alabama, USA

4. Department of Pharmcology, University of South Alabama College of Medicine, Mobile, Alabama, USA

5. Women’s Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA

Abstract

Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen that causes nosocomial pneumonia, urinary tract infections, and bacteremia. A hallmark of P. aeruginosa pathogenesis is disruption of host cell function by the type III secretion system (T3SS) and its cognate exoenzyme effectors.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00470-21

Reference77 articles.

1. Centers for Disease Control and Prevention. 2013. Antibiotic resistance threats in the United States, 2013. Centers for Disease Control and Prevention, Atlanta, GA.

2. Prevalence of type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa

3. Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa

4. Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia

5. Type III Protein Secretion Is Associated with Death in Lower Respiratory and SystemicPseudomonas aeruginosaInfections

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Amyloid-β and caspase-1 are indicators of sepsis and organ injury;ERJ Open Research;2023-12-21

2. The roles of autophagy and mitophagy in corneal pathology: current knowledge and future perspectives;Frontiers in Medicine;2023-04-21

3. Extracellular vesicle-mediated regulation of macrophage polarization in bacterial infections;Frontiers in Microbiology;2022-12-22

4. Autophagy in the normal and diseased cornea;Experimental Eye Research;2022-12

5. Modulation of the immune response by the Pseudomonas aeruginosa type-III secretion system;Frontiers in Cellular and Infection Microbiology;2022-11-28