Cellular Mn/Zn Ratio Influences Phosphoglucomutase Activity and Capsule Production in Streptococcus pneumoniae D39-Reference-Cited by-同舟云学术

Cellular Mn/Zn Ratio Influences Phosphoglucomutase Activity and Capsule Production in Streptococcus pneumoniae D39

Published:2021-06-08 Issue:13 Volume:203 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

McFarland Averi L.¹,Bhattarai Nabin¹,Joseph Merrin²,Winkler Malcolm E.²,Martin Julia E.¹^ORCID

Affiliation:

1. Department of Biological Sciences, Idaho State University, Pocatello, Idaho, USA

2. Department of Biology, Indiana University, Bloomington, Indiana, USA

Abstract

Evolving evidence strongly indicates that maintenance of metal homeostasis is essential for establishing colonization and continued growth of bacterial pathogens in the vertebrate host. In this study, we demonstrate the impact of cellular manganese/zinc (Mn/Zn) ratios on bacterial capsular polysaccharide (CPS) production, an important virulence determinant of many human-pathogenic bacteria, including Streptococcus pneumoniae .

Funder

ISU INBRE graduate fellowship award

Institutional Development Award (IDeA) from NIGMS

HHS | NIH | National Institute of General Medical Sciences

Idaho State University

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00602-20

Reference101 articles.