A Novel Broad Allele-Specific TaqMan Real-Time PCR Method To Detect Triazole-Resistant Strains of Aspergillus fumigatus, Even with a Very Low Percentage of Triazole-Resistant Cells Mixed with Triazole-Susceptible Cells-Reference-Cited by-全球学者库

A Novel Broad Allele-Specific TaqMan Real-Time PCR Method To Detect Triazole-Resistant Strains of Aspergillus fumigatus, Even with a Very Low Percentage of Triazole-Resistant Cells Mixed with Triazole-Susceptible Cells

Published:2019-09 Issue:9 Volume:57 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Wang Qian¹²³,Kontoyiannis Dimitrios P.⁴^ORCID,Li Ruoyu¹²³,Chen Wei¹²³,Bu Dingfang¹,Liu Wei¹²³

Affiliation:

1. Department of Dermatology, Peking University First Hospital, Beijing, China

2. Research Center for Medical Mycology, Peking University, Beijing, China

3. Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China

4. Department of Infectious Disease, Infection Control and Employee Health, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

Abstract

Invasive aspergillosis caused by triazole-resistant strains of Aspergillus fumigatus is a growing public health concern, as is the occurrence of mixed infections with triazole-resistant and -susceptible A. fumigatus strains. Therefore, it is crucial to develop robust methods to identify triazole-resistant strains of A. fumigatus , even in mixtures of triazole-resistant and -susceptible strains of A. fumigatus .

Funder

National Science and Technology Major Project

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00604-19

Reference32 articles.

1. The clinical spectrum of pulmonary aspergillosis

2. Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America