Methylation of PhoP by CheR Regulates Salmonella Virulence

Author:

Su Yang1,Li Jianhui1ORCID,Zhang Wenting1,Ni Jinjing1,Huang Rui1,Wang Zuoqiang1,Cheng Sen2,Wang Yue3,Tian Zhixin3,Zhou Qiuxiang4,Lin Donghai4,Wu Wenjuan5,Tang Christoph M.6,Liu Xiaoyun2,Lu Jie7ORCID,Yao Yu-Feng189ORCID

Affiliation:

1. Laboratory of Bacterial Pathogenesis, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China

2. Department of Microbiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China

3. School of Chemical Science & Engineering, Shanghai Key Laboratory of Chemical Assessment and Sustainability, Tongji University, Shanghai, China

4. College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China

5. Department of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China

6. Sir William Dunn School of Pathology, University of Oxford, Oxford, UK

7. Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

8. School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China

9. Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai, China

Abstract

Posttranslational modifications (PTMs) play an important role in regulating enzyme activities, protein-protein interactions, or DNA-protein recognition and, consequently, modulate many biological functions. We demonstrated that PhoP, the response regulator of PhoP/PhoQ two-component system, could be methylated on several evolutionally conserved amino acid residues.

Funder

National Natural Science Foundation of China

State key development programs for basic research of China

Key research and development project of China

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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