The art gene product of human immunodeficiency virus is required for replication

Author:

Terwilliger E1,Burghoff R1,Sia R1,Sodroski J1,Haseltine W1,Rosen C1

Affiliation:

1. Dana-Farber Cancer Institute, Boston, Massachusetts 02115.

Abstract

A mutation that alters the initiation codon of the art gene of the human immunodeficiency virus renders the virus replication defective. The replication defect of this mutation can be complemented in trans by the art gene product. These findings indicate that the art protein is essential for replication and, as such, represents a good target for development of new antiviral agents that could be useful in the control of human immunodeficiency virus infection.

Publisher

American Society for Microbiology

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