Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase-Reference-Cited by-同舟云学术

Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase

Published:2021-02-23 Issue:1 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Nozawa Takashi¹,Iibushi Junpei¹,Toh Hirotaka¹,Minowa-Nozawa Atsuko¹,Murase Kazunori¹^ORCID,Aikawa Chihiro¹,Nakagawa Ichiro¹^ORCID

Affiliation:

1. Department of Microbiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Abstract

Two prominent virulence factors of group A Streptococcus (GAS), streptolysin O (SLO) and NAD-glycohydrolase (Nga), are linked to enhanced pathogenicity of the prevalent GAS strains. Recent advances show that SLO and Nga are important for intracellular survival of GAS in epithelial cells and macrophages.

Funder

Japan Agency for Medical Research and Development

Ministry of Education, Culture, Sports, Science and Technology

Takeda Science Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01974-20

Reference58 articles.

1. Molecular insight into invasive group A streptococcal disease