Control of HIV-1 Replication by CD8 <sup>+</sup> T Cells Specific for Two Novel Pol Protective Epitopes in HIV-1 Subtype A/E Infection-Reference-Cited by-同舟云学术

Control of HIV-1 Replication by CD8 ⁺ T Cells Specific for Two Novel Pol Protective Epitopes in HIV-1 Subtype A/E Infection

Published:2022-10-12 Issue:19 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Nguyen Hung The¹,Kuse Nozomi¹,Zhang Yu¹,Murakoshi Hayato¹,Maeda Yosuke²^ORCID,Tamura Yoshiko¹,Maruyama Rie¹,Tran Giang Van³⁴,Nguyen Trung Vu⁴,Nguyen Kinh Van³,Oka Shinichi⁵,Chikata Takayuki¹,Takiguchi Masafumi¹^ORCID

Affiliation:

1. Division of International Collaboration Research and Tokyo Joint Laboratory, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

2. Department of Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

3. National Hospital of Tropical Diseases, Hanoi, Vietnam

4. Hanoi Medical University, Hanoi, Vietnam

5. AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan

Abstract

It is expected that HIV-1-specific CD8 + T cells that effectively suppress HIV-1 replication will contribute to HIV-1 vaccine development and therapy to achieve an HIV cure. T cells specific for protective epitopes were identified in HIV-1 subtype B and C infections but not in subtype A/E infection, which is epidemic in Southeast Asia.

Funder

Japan Agency for Medical Research and Development

The Institute of Tropical Medicine, Nagasaki University

Ministry of Education, Culture, Sports, Science and Technology

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00811-22

Reference51 articles.

1. Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover

2. CD8+ T cell efficacy in vaccination and disease

3. CD8+ T cells in HIV control, cure and prevention

4. Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

5. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome