Mechanisms of Internalization of Staphylococcus aureus by Cultured Human Osteoblasts-Reference-Cited by-全球学者库

Mechanisms of Internalization of Staphylococcus aureus by Cultured Human Osteoblasts

Published:1999-05 Issue:5 Volume:67 Page:2677-2681
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Jevon Marc¹,Guo Chuanbin¹,Ma Beechai¹,Mordan Nicky²,Nair Sean P.¹,Harris Malcolm¹,Henderson Brian¹,Bentley George³,Meghji Sajeda¹

Affiliation:

1. Maxillofacial Surgery Research Unit1 and

2. Electron Microscopy Unit,2 Eastman Dental Institute, University College London, London, and

3. Institute of Orthopaedics, Royal National Orthopaedic Hospital Trust, Stanmore, Middlesex,3 United Kingdom

Abstract

ABSTRACT Staphylococcus aureus is an important bone pathogen, and evidence shows that this organism is internalized by chick osteoblasts. Here we report that S. aureus is internalized by human osteoblasts. Internalization was inhibited by monodansylcadaverine and cytochalasin D and to a lesser extent by ouabain, monensin, colchicine, and nocodazole. We propose that internalization occurs via a receptor-mediated pathway, requiring the participation of cytoskeletal elements, principally actin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.67.5.2677-2681.1999

Reference35 articles.

1. Staphylococcus aureus invasion of bovine mammary cells;Almeida R. A.;J. Dairy Sci.,1996

2. Effect of Staphylococcus aureus extracellular proteinaceous fraction in an isolated osteoclastic resorption assay;Arora M.;J. Bone Miner. Metab.,1998

3. Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts;Basu S. K.;Cell,1981

4. Intracellular Staphylococcus aureus Escapes the Endosome and Induces Apoptosis in Epithelial Cells

5. Infection of human vascular endothelial cells with Staphylococcus aureus induces hyperadhesiveness for human monocytes and granulocytes;Beekhuizen H.;J. Immunol.,1997

Cited by 150 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Integrative tissue, cellular and molecular responsiveness of an innovative ex vivo model of the Staphylococcus aureus‐mediated bone infection;The FASEB Journal;2023-08-31

2. Repurposed Fenoprofen Targeting SaeR Attenuates Staphylococcus aureus Virulence in Implant-Associated Infections;ACS Central Science;2023-06-15

3. Atopic dermatitis-derived Staphylococcus aureus strains: what makes them special in the interplay with the host;Frontiers in Cellular and Infection Microbiology;2023-06-14

4. Catch Bond-Mediated Adhesion Drives Staphylococcus aureus Host Cell Invasion;Nano Letters;2023-06-02

5. Quinoxaline-based membrane-targeting therapeutic material: Implications in rejuvenating antibiotic and curb MRSA invasion in an in vitro bone cell infection model;Biomaterials Advances;2023-05