Affiliation:
1. Department of Biological Engineering
2. Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
Abstract
ABSTRACT
Acute diarrheal illness is a global health problem that may be exacerbated by concurrent infection. Using
Citrobacter rodentium
, a murine model of attaching and effacing diarrheagenic
Escherichia coli
, we demonstrate that persistent
Helicobacter hepaticus
infection modulates host responses to diarrheal disease, resulting in delayed recovery from weight loss and from tissue damage. Chronic colitis in concurrently infected mice is characterized by macrophage and Foxp3
+
regulatory T-cell accumulation. Prolonged disease is also associated with increased interleukin-17 expression, which may be due to suppression of gamma interferon during the acute phase of diarrheal infection. This new model of polymicrobial infection provides insight into the mechanism by which subclinical infection can exacerbate morbidity due to an unrelated self-limiting infection.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
18 articles.
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