Affiliation:
1. Department of Microbiology and Molecular Genetics, University of California, Davis, California, USA
Abstract
Entamoeba histolytica
causes amoebiasis, a potentially fatal diarrheal disease. Abscesses in organs such as the liver can occur when amoebae are able to breach the intestinal wall and travel through the bloodstream to other areas of the body. Therefore, understanding how
E. histolytica
evades immune detection is of great interest. Here, we demonstrate for the first time that
E. histolytica
acquires and displays human cell membrane proteins by taking “bites” of human cell material in a process named trogocytosis (“trogo-” means “nibble”), and that this allows amoebae to survive in human serum. Display of acquired proteins through trogocytosis has been previously characterized only in mammalian immune cells. Our study suggests that this is a more general feature of trogocytosis not restricted to immune cells and broadens our knowledge of eukaryotic biology. These findings also reveal a novel strategy for immune evasion by a pathogen and may apply to the pathogenesis of other infections.
Publisher
American Society for Microbiology
Cited by
28 articles.
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