SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98-Reference-Cited by-同舟云学术

SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Addetia Amin¹²,Lieberman Nicole A. P.¹,Phung Quynh¹,Hsiang Tien-Ying³,Xie Hong¹,Roychoudhury Pavitra¹³,Shrestha Lasata¹,Loprieno Michelle A.¹,Huang Meei-Li¹,Gale Michael³,Jerome Keith R.¹⁴,Greninger Alexander L.¹⁴^ORCID

Affiliation:

1. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA

2. Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, USA

3. Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, Washington, USA

4. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

Abstract

SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), is an RNA virus with a large genome that encodes multiple accessory proteins. While these accessory proteins are not required for growth in vitro , they can contribute to the pathogenicity of the virus.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00065-21

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