Deep Infection by Trichophyton rubrum in an Immunocompromised Patient

Author:

Nir-Paz Ran12,Elinav Hila2,Pierard Gerald E.3,Walker David4,Maly Alexander5,Shapiro Mervyn1,Barton Richard C.4,Polacheck Itzhack1

Affiliation:

1. Departments of Clinical Microbiology and Infectious Diseases

2. Medicine

3. Department of Dermatopathology, University Medical Center Sart Tilman, Liège, Belgium

4. Division of Microbiology, University of Leeds and Mycology Reference Center, General Infirmary, Leeds LS2 9JT, United Kingdom

5. Pathology, Hadassah—Hebrew University Medical Center, Jerusalem, Israel

Abstract

ABSTRACT Dermatophytes are common pathogens of skin but rarely cause invasive disease. We present a case of deep infection by Trichophyton rubrum in an immunocompromised patient. T. rubrum was identified by morphological characteristics and confirmed by PCR. Invasiveness was apparent by histopathology and immunohistochemistry. The patient was treated successfully with itraconazole.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference22 articles.

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2. Araviysky, A. N., R. A. Araviysky, and G. A. Eschkov. 1975. Deep generalized trichophytosis. (Endothrix in tissues of different origin.) Mycopathologia56:47-65.

3. Arrese, J. E., C. Pierard-Franchimont, and G. E. Pierard. 1996. Fatal hyalohyphomycosis following Fusarium onychomycosis in an immunocompromised patient. Am. J. Dermatopathol.18:196-198.

4. Chastain, M. A., R. J. Reed, and G. A. Pankey. 2001. Deep dermatophytosis: report of 2 cases and review of the literature. Cutis67:457-462.

5. de Hoog G. S. J. Guarro J. Gene and M. J. Figueras. 2000. Genus: Trichophyton p. 954-994. Atlas of clinical fungi 2nd ed. Centraalbureau voor Schimmelcultures Utrecht The Netherlands.

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