Clinical and Molecular Epidemiology of Human Parainfluenza Virus 4 Infections in Hong Kong: Subtype 4B as Common as Subtype 4A

Author:

Lau Susanna K. P.123,Li Kenneth S. M.3,Chau Kam-yu3,So Lok-yee4,Lee Rodney A.5,Lau Yu-lung6,Chan Kwok-hung3,Lim Wilina W. L.7,Woo Patrick C. Y.123,Yuen Kwok-yung123

Affiliation:

1. State Key Laboratory of Emerging Infectious Diseases

2. Research Centre of Infection and Immunology

3. Department of Microbiology, The University of Hong Kong, Hong Kong

4. Department of Paediatrics and Adolescent Medicine

5. Department of Pathology, Pamela Youde Nethersole Eastern Hospital, Hong Kong

6. Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong

7. Public Health Laboratory Centre, Centre for Health Protection, Hong Kong

Abstract

ABSTRACT In this 1-year study, 35 (1.2%) of 2,912 nasopharyngeal aspirates were positive for human parainfluenza virus 4 (HPIV4) by reverse transcription-PCR. Patients with HPIV4 infection were mainly young children and immunocompromised adults. In contrast to the reported predominance of HPIV4A infection, molecular subtyping revealed that 15 (44%) cases were caused by HPIV4B.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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