Usefulness of Automated Latex Turbidimetric Rapid Plasma Reagin Test for Diagnosis and Evaluation of Treatment Response in Syphilis in Comparison with Manual Card Test: a Prospective Cohort Study

Author:

Tsuboi Motoyuki1,Nishijima Takeshi1,Aoki Takahiro1,Teruya Katsuji1,Kikuchi Yoshimi1,Gatanaga Hiroyuki1,Oka Shinichi1

Affiliation:

1. AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan

Abstract

The usefulness of an automated latex turbidimetric rapid plasma reagin (RPR) assay, compared to the conventional manual card test (serial 2-fold dilution method), for the diagnosis of syphilis and evaluation of treatment response remains unknown. We conducted (i) a cross-sectional study and (ii) a prospective cohort study to elucidate the correlation between automated and manual tests and whether a 4-fold decrement is a feasible criterion for successful treatment with the automated test, respectively, in HIV-infected patients, from October 2015 to November 2017.

Funder

National Center for Global Health and Medicine

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference20 articles.

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4. Sexually transmitted diseases treatment guidelines, 2015;Workowski KA;MMWR Recommend Rep,2015

5. Sensitivity, specificity and likelihood ratios of PCR in the diagnosis of syphilis: a systematic review and meta-analysis

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