A Derivative of the D5 Monoclonal Antibody That Targets the gp41 N-Heptad Repeat of HIV-1 with Broad Tier-2-Neutralizing Activity

Author:

Rubio Adonis A.12ORCID,Filsinger Interrante Maria V.134,Bell Benjamin N.15,Brown Clayton L.16,Bruun Theodora U. J.16ORCID,LaBranche Celia C.78ORCID,Montefiori David C.78,Kim Peter S.169ORCID

Affiliation:

1. Stanford ChEM-H, Stanford University, Stanford, California, USA

2. Department of Biology, Stanford University School of Humanities & Sciences, Stanford, California, USA

3. Stanford Biophysics Program, Stanford University School of Medicine, Stanford, California, USA

4. Stanford Medical Scientist Training Program, Stanford University School of Medicine, Stanford, California, USA

5. Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, USA

6. Department of Biochemistry, Stanford University School of Medicine, Stanford, California, USA

7. Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA

8. Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA

9. Chan Zuckerberg Biohub, San Francisco, California, USA

Abstract

Despite advances in antiretroviral therapy, HIV remains a global epidemic and has claimed more than 32 million lives. Accordingly, developing an effective HIV vaccine remains an urgent public health need.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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