MarR-Dependent Transcriptional Regulation of <i>mmpSL5</i> Induces Ethionamide Resistance in Mycobacterium abscessus-Reference-Cited by-同舟云学术

MarR-Dependent Transcriptional Regulation of mmpSL5 Induces Ethionamide Resistance in Mycobacterium abscessus

Published:2023-04-18 Issue:4 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Rodriguez Ronald¹,Campbell-Kruger Nick²,Gonzalez Camba Jesus²,Berude John²,Fetterman Rachel²,Stanley Sarah²^ORCID

Affiliation:

1. Department of Plant & Microbial Biology, University of California, Berkeley, California, USA

2. Department of Molecular & Cell Biology, University of California, Berkeley, California, USA

Abstract

Mycobacterium abscessus ( Mabs ) is an emerging nontuberculosis mycobacterial (NTM) pathogen responsible for a wide variety of respiratory and cutaneous infections that are difficult to treat with standard antibacterial therapy. Mabs has a high degree of both innate and acquired antibiotic resistance to most clinically relevant drugs, including standard anti-mycobacterial agents. Ethionamide (ETH), an inhibitor of mycolic acid biosynthesis, is currently utilized as a second-line agent for treating multidrug-resistant tuberculosis infections.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01350-22

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