Comparison of Abilities of Salmonella enterica Serovar Typhimurium aroA aroD and aroA htrA Mutants To Act as Live Vectors-Reference-Cited by-同舟云学术

Comparison of Abilities of Salmonella enterica Serovar Typhimurium aroA aroD and aroA htrA Mutants To Act as Live Vectors

Published:2000-10 Issue:10 Volume:68 Page:6041-6043
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Roberts Mark¹,Chatfield Steven²,Pickard Derek²,Li Jingli²,Bacon Andrew²

Affiliation:

1. Department of Veterinary Pathology, Glasgow University Veterinary School, Glasgow G61 1QH,1and

2. Vaccine Research Unit, Medeva, Department of Biochemistry, Imperial College of Science, Technology, and Medicine, London SW7 2AZ,2 United Kingdom

Abstract

ABSTRACT We compared the ability of Salmonella enterica serovar Typhimurium SL1344 aroA aroD (BRD509) and aroA htrA (BRD807) mutants to act as live vectors for delivery of fragment C of tetanus toxin (FrgC). FrgC was expressed in these strains from either pTETnir15 or pTEThtrA1. BRD509FrgC + strains elicited ∼2-log-higher serum anti-FrgC antibody titers than BRD807FrgC + strains. All mice immunized with BRD807pTEThtrA1, BRD509pTEThtrA1, and BRD509pTETnir15 (but not BRD807pTETnir15) were protected against tetanus.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.10.6041-6043.2000

Reference13 articles.

1. Evaluation of Salmonella typhimurium strains harbouring defined mutations in htrA and aroA in the murine salmonellosis model;Chatfield S. N.;Microb. Pathog.,1992

2. Oral somatic transgene vaccination using attenuated S. typhimurium;Darji A.;Cell,1997

3. Comparison of the Abilities of Different Attenuated Salmonella typhimurium Strains To Elicit Humoral Immune Responses against a Heterologous Antigen

4. The alternative sigma factor, sigmaE, is critically important for the virulence of Salmonella typhimurium;Humphreys S.;Infect. Immun.,1999

5. Attenuated Salmonella as live oral vaccines against typhoid fever and as live vectors;Levine M. M.;J. Biotechnol.,1996

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