Adaptation of HIV-1/HIV-2 Chimeras with Defects in Genome Packaging and Viral Replication

Author:

Rawson Jonathan M. O.1,Nikolaitchik Olga A.1,Yoo Jennifer A.1,Somoulay Xayathed1,Brown Matthew A.1,Mbuntcha Bogni Franck S.1,Pathak Vinay K.2ORCID,Soheilian Ferri3,Slack Ryan L.4,Sarafianos Stefan G.4ORCID,Hu Wei-Shau1ORCID

Affiliation:

1. Viral Recombination Section, HIV Dynamics and Replication Program, NCI, Frederick, Maryland, USA

2. Viral Mutation Section, HIV Dynamics and Replication Program, NCI, Frederick, Maryland, USA

3. Electron Microscopy Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA

4. Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA

Abstract

Novel retroviruses can emerge from recombination between distantly related retroviruses. Most notably, HIV-1 originated from zoonotic transmission of a novel recombinant (SIV cpz ) into humans.

Funder

HHS | National Institutes of Health

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference76 articles.

1. Goff SP. 2013. Retroviridae: the retroviruses and their replication, p 1424–1472. In Knipe DM, Howley PM. (ed), Fields virology, 6th ed, vol 2. Lippincott Williams and Wilkins, Philadelphia, PA, USA.

2. Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus

3. Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses

4. The DNA Provirus Hypothesis

5. Mechanisms and Factors that Influence High Frequency Retroviral Recombination

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