Influenza A Virus Defective Viral Genomes Are Inefficiently Packaged into Virions Relative to Wild-Type Genomic RNAs-Reference-Cited by-同舟云学术

Influenza A Virus Defective Viral Genomes Are Inefficiently Packaged into Virions Relative to Wild-Type Genomic RNAs

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Alnaji Fadi G.¹^ORCID,Reiser William K.¹,Rivera-Cardona Joel¹,te Velthuis Aartjan J. W.²^ORCID,Brooke Christopher B.¹³^ORCID

Affiliation:

1. Department of Microbiology, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA

2. Lewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA

3. Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA

Abstract

Defective interfering particles (DIPs) are commonly produced by RNA viruses and have been implicated in modulating clinical infection outcomes; hence, there is increasing interest in the potential of DIPs as antiviral therapeutics. For influenza viruses, DIPs are formed by the packaging of genomic RNAs harboring internal deletions.

Funder

DOD | Defense Advanced Research Projects Agency

Wellcome

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02959-21

Reference49 articles.

1. Population Diversity and Collective Interactions during Influenza Virus Infection