Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing-Reference-Cited by-同舟云学术

Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing

Published:2019-08 Issue:8 Volume:57 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Fu Ya¹²,Zeng Yongbin¹²,Chen Tianbin¹²,Chen Huijuan¹²,Lin Ni¹²,Lin Jinpiao¹²,Liu Xiaofeng¹²,Huang Er¹²,Wu Songhang¹²,Wu Shu¹²,Xu Siyi¹²,Wang Long¹²,Ou Qishui¹²

Affiliation:

1. First Clinical College, Fujian Medical University, Fuzhou, China

2. Department of Laboratory Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

Abstract

Mutations in hepatitis B virus (HBV) reverse transcriptase (RT) are associated with nucleos(t)ide analogue (NA) resistance during long-term antiviral treatment. However, the characterization of mutations in HBV RT in untreated patients has not yet been well illustrated. The objective of this study was to investigate the characterization and clinical significance of natural variability in HBV RT in treatment-naive patients.

Funder

Joint Funds for the innovation of science and Technology, Fujian province

Starup Fund for scientific research, Fujian Medical University

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00119-19

Reference31 articles.

1. How to control highly endemic hepatitis B in Asia