Can Molecular Methods Detect 1% Isoniazid Resistance in Mycobacterium tuberculosis?-Reference-Cited by-同舟云学术

Can Molecular Methods Detect 1% Isoniazid Resistance in Mycobacterium tuberculosis?

Published:2013-05 Issue:5 Volume:51 Page:1596-1599
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Folkvardsen Dorte Bek¹,Svensson Erik¹,Thomsen Vibeke Ø.¹,Rasmussen Erik Michael¹,Bang Didi¹,Werngren Jim²,Hoffner Sven²,Hillemann Doris³,Rigouts Leen⁴

Affiliation:

1. International Reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark

2. Swedish Institute for Communicable Diseases Control, Solna, Sweden

3. Forschungszentrum Borstel, National Reference Center for Mycobacteria, Borstel, Germany

4. Mycobacteriology Unit, Institute of Tropical Medicine, Antwerp, Belgium

Abstract

ABSTRACT Patients may harbor both drug-susceptible and -resistant bacteria, representing heteroresistance. We studied mixtures of isoniazid-resistant and -susceptible Mycobacterium tuberculosis strains. Conventional drug susceptibility testing was the most sensitive method of detection, whereas the line probe assay and sequencing were not able to detect the clinically relevant 1% proportion of resistant bacteria.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00472-13

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