Vancomycin-Variable Enterococcus faecium: <i>In Vivo</i> Emergence of Vancomycin Resistance in a Vancomycin-Susceptible Isolate-Reference-Cited by-同舟云学术

Vancomycin-Variable Enterococcus faecium: In Vivo Emergence of Vancomycin Resistance in a Vancomycin-Susceptible Isolate

Published:2014-05 Issue:5 Volume:52 Page:1766-1767
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Coburn Bryan¹,Low Donald E.¹²³,Patel Samir N.³⁴,Poutanen Susan M.¹²³,Shahinas Dea⁴,Eshaghi Alireza⁴,Willey Barbara M.²,McGeer Allison¹²³

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Canada

2. Department of Microbiology, University Health Network/Mount Sinai Hospital, Toronto, Canada

3. Division of Medical Microbiology, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada

4. Public Health Ontario, Public Health Laboratory, Toronto, Canada

Abstract

ABSTRACT We report the emergence of vancomycin resistance in a patient colonized with a vanA -containing, vanRS -negative isolate of Enterococcus faecium which was initially vancomycin susceptible. This is a previously undescribed mechanism of drug resistance with diagnostic and therapeutic implications.

Publisher

American Society for Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.03579-13

Reference11 articles.

1. Clinical and Laboratory Standards Institute M100-S24. 2014. Performance standards for antimicrobial susceptibility testing; twenty-fourth informational supplement. Clinical and Laboratory Standards Institute, Wayne, PA.

2. Outbreak of Vancomycin-Susceptible Enterococcus faecium Containing the Wild-Type vanA Gene

3. Plasmid-Mediated Resistance to Vancomycin and Teicoplanin in Enterococcus Faecium

4. VANCOMYCIN-RESISTANT ENTEROCOCCI

5. Vancomycin Resistance in Gram-Positive Cocci

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