Impacts of the Plateau Environment on the Gut Microbiota and Blood Clinical Indexes in Han and Tibetan Individuals-Reference-Cited by-全球学者库

Impacts of the Plateau Environment on the Gut Microbiota and Blood Clinical Indexes in Han and Tibetan Individuals

Published:2020-02-11 Issue:1 Volume:5 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Jia Zhilong¹²³^ORCID,Zhao Xiaojing¹²,Liu Xiaoshuang⁴,Zhao Le⁵⁶,Jia Qian¹²,Shi Jinlong²³,Xu Xiao⁴,Hao Lijun¹²,Xu Zhenguo¹²,Zhong Qin¹²,Yu Kang²³,Cui Saijia¹²,Chen Huining¹²,Guo Jianying⁴,Li Xiang⁴,Han Yang¹²,Song Xinyu¹³,Zhao Chenghui¹³,Bo Xiaochen⁷,Tian Yaping¹²,Wang Weidong²³,Xie Guotong⁴,Feng Qiang⁵⁶,He Kunlun¹²³

Affiliation:

1. Beijing Key Laboratory for Precision Medicine of Chronic Heart Failure, Chinese PLA General Hospital, Beijing, China

2. Laboratory of Translational Medicine, Chinese PLA General Hospital, Beijing, China

3. Key Laboratory of Biomedical Engineering and Translational Medicine, Ministry of Industry and Information Technology, Chinese PLA General Hospital, Beijing, China

4. Ping An Health Technology, Beijing, China

5. Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Department of Human Microbiome, School of Stomatology, Shandong University, Jinan, Shandong, China

6. State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong, China

7. Beijing Institute of Radiation Medicine, Beijing, China

Abstract

The data presented in the present study demonstrate that the hypoxic plateau environment has a profound impact on the gut microbiota and blood clinical indexes in Han and Tibetan individuals. The plateau-changed signatures of the gut microbiota and blood clinical indexes were not restored to the nonplateau status in the Han cohorts, even when the individuals returned to the plain from the plateau for several months. Our study will improve the understanding of the great impact of hypoxic environments on the gut microbiota and blood clinical indexes as well as the adaptation mechanism and intervention targets for plateau adaptation.

Funder

National Key Research and Development Program of China

Natural Science of Shandong Provice

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00660-19

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