Microbiota-Derived Short-Chain Fatty Acids Promote LAMTOR2-Mediated Immune Responses in Macrophages-Reference-Cited by-同舟云学术

Microbiota-Derived Short-Chain Fatty Acids Promote LAMTOR2-Mediated Immune Responses in Macrophages

Published:2020-12-22 Issue:6 Volume:5 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Wu Ting¹,Li Hongru²,Su Cong³,Xu Fangming¹,Yang Guangwei¹,Sun Kaili¹,Xu Mengran¹,Lv Na¹,Meng Bao¹,Liu Yanyan⁴⁵,Hu Lifen¹,Liu Yan⁶,Gao Yufeng¹,Wang Heng⁷,Lan Yanhu⁴⁵,Xu Dexiang⁸,Li Jiabin¹³⁴⁵

Affiliation:

1. Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

2. XiangYa School of Medicine, Central South University, Changsha, Hunan, China

3. Department of Infectious Diseases, The Chaohu Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

4. Anhui Center for Surveillance of Bacterial Resistance, Hefei, Anhui, China

5. Institute of Bacterial Resistance, Anhui Medical University, Hefei, Anhui, China

6. Department of Basic Medical, Anhui Medical University, Hefei, Anhui, China

7. Department of Hospital Management, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

8. Laboratory of Environmental Toxicology, Department of Toxicology, Anhui Medical University, Hefei, Anhui, China

Abstract

These observations highlight that SCFAs promote macrophage elimination of K. pneumoniae via a LAMTOR2-dependent signal pathway and suggest that it is possible to intervene in K. pneumoniae pneumonia by targeting the gut microbiota.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00587-20

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