Application of Traditional Vaccine Development Strategies to SARS-CoV-2

Author:

Rando Halie M.1234ORCID,Lordan Ronan156ORCID,Lee Alexandra J.1ORCID,Naik Amruta7,Wellhausen Nils1ORCID,Sell Elizabeth6,Kolla Likhitha6,Gitter Anthony89ORCID,Greene Casey S.123410ORCID,Bansal Vikas,Barton John P.,Boca Simina M.,Boerckel Joel D.,Brueffer Christian,Byrd James Brian,Capone Stephen,Das Shikta,Dattoli Anna Ada,Dziak John J.,Field Jeffrey M.,Ghosh Soumita,Gitter Anthony,Goel Rishi Raj,Greene Casey S.,Guebila Marouen Ben,Himmelstein Daniel S.,Hu Fengling,Jadavji Nafisa M.,Kamil Jeremy P.,Knyazev Sergey,Kolla Likhitha,Lee Alexandra J.,Lordan Ronan,Lubiana Tiago,Lukan Temitayo,MacLean Adam L.,Mai David,Mangul Serghei,Manheim David,McGowan Lucy D’Agostino,Meyer Jesse G.,Mundo Ariel I.,Naik Amruta,Park YoSon,Perrin Dimitri,Qi Yanjun,Rafizadeh Diane N.,Ramsundar Bharath,Rando Halie M.,Ray Sandipan,Robson Michael P.,Rubinetti Vincent,Sell Elizabeth,Shinholster Lamonica,Skelly Ashwin N.,Sun Yuchen,Sun Yusha,Szeto Gregory L.,Velazquez Ryan,Wang Jinhui,Wellhausen Nils, ,

Affiliation:

1. Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA

2. Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora, Colorado, USA

3. Center for Health AI, University of Colorado School of Medicine, Aurora, Colorado, USA

4. Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, USA

5. Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

6. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, USA

7. Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

8. Department of Biostatistics and Medical Informatics, University of Wisconsin—Madison, Madison, Wisconsin, USA

9. Morgridge Institute for Research, Madison, Wisconsin, USA

10. Childhood Cancer Data Lab, Alex’s Lemonade Stand Foundation, Philadelphia, Pennsylvania, USA

Abstract

The development, production, and distribution of vaccines is imperative to saving lives, preventing illness, and reducing the economic and social burdens caused by the COVID-19 pandemic. Vaccines that use cutting-edge biotechnology have played an important role in mitigating the effects of SARS-CoV-2.

Funder

NIH Medical Scientist Training Program T32

John W. and Jeanne M. Rowe Center for Research in Virology

Gordon and Betty Moore Foundation

HHS | NIH | National Human Genome Research Institute

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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