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Stat3 Activation Is Required for Cellular Transformation by v- src

Published:1998-05 Issue:5 Volume:18 Page:2553-2558
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Bromberg Jacqueline F.¹,Horvath Curt M.¹,Besser Daniel²,Lathem Wyndham W.¹,Darnell James E.¹

Affiliation:

1. Laboratory of Molecular Cell Biology 1 and

2. Laboratory of Molecular Oncology, 2 The Rockefeller University, New York, New York 10021-6399

Abstract

ABSTRACT Stat3 activation has been associated with cytokine-induced proliferation, anti-apoptosis, and transformation. Constitutively activated Stat3 has been found in many human tumors as well as v- abl - and v- src -transformed cell lines. Because of these correlations, we examined directly the relationship of activated Stat3 to cellular transformation and found that wild-type Stat3 enhances the transforming potential of v- src while three dominant negative Stat3 mutants inhibit v- src transformation. Stat3 wild-type or mutant proteins did not affect v- ras transformation. We conclude that Stat3 has a necessary role in v- src transformation.

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.18.5.2553

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