Deletion of <i>cox7c</i> Results in Pan-Azole Resistance in Aspergillus fumigatus-Reference-Cited by-同舟云学术

Deletion of cox7c Results in Pan-Azole Resistance in Aspergillus fumigatus

Published:2022-06-21 Issue:6 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chen Mingcong¹,Zhong Guowei¹^ORCID,Wang Sha²,Chen Peiying³,Li Lei¹

Affiliation:

1. Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China

2. Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, Huzhou University, Huzhou Central Hospital, Huzhou, China

3. School of Medicine and Life Science, Nanjing University of Chinese Medicine, Nanjing, China

Abstract

In Aspergillus fumigatus , the most prevalent resistance to azoles results from mutational modifications of the azole target protein Cyp51A, but there are non- cyp51A mutants resistant to azoles, and the mechanisms underlying the resistance of these strains remain to be explored. Here, we identified a novel cytochrome c oxidase, cox7c (W56*), nonsense mutation in the laboratory and found that it caused reduced colony growth and resistance to multiantifungal agents.

Funder

National Natural Science Foundation of China

Priority Academic Program Development of Jiangsu Higher Education Institutions

Public Welfare Research Program of Huzhou Science and Technology Bureau

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00151-22

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