Prevalence, Characteristics, and Molecular Epidemiology of Macrolide and Fluoroquinolone Resistance in Clinical Isolates of Streptococcus pneumoniae at Five Tertiary-Care Hospitals in Korea-Reference-Cited by-同舟云学术

Prevalence, Characteristics, and Molecular Epidemiology of Macrolide and Fluoroquinolone Resistance in Clinical Isolates of Streptococcus pneumoniae at Five Tertiary-Care Hospitals in Korea

Published:2007-07 Issue:7 Volume:51 Page:2625-2627
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Shin Jeong Hwan¹²,Jung Hee Jung¹²,Kim Hye Ran¹,Jeong Joseph³,Jeong Seok Hoon⁴,Kim Sunjoo⁵,Lee Eun Yup⁶,Lee Jeong Nyeo¹²,Chang Chulhun Ludgerus⁶⁷

Affiliation:

1. Department of Laboratory Medicine

2. Paik Institute for Clinical Research, College of Medicine, Inje University, Busan

3. Department of Laboratory Medicine, College of Medicine, Ulsan University, Ulsan

4. Department of Laboratory Medicine, College of Medicine, Kosin University, Busan

5. Department of Laboratory Medicine, School of Medicine, Gyeongsang National University, Jinju

6. Department of Laboratory Medicine, School of Medicine

7. Medical Research Institute, Pusan National University, Busan, Korea

Abstract

ABSTRACT The genes erm (B), mef (A), and both erm (B) and mef (A) were identified in 42.6, 10.1, and 47.3%, respectively, of the erythromycin-resistant Streptococcus pneumoniae isolates. Of the strains, 3.8% were nonsusceptible to levofloxacin and had 1 to 6 amino acid changes in the quinolone resistance-determining region, including a new mutation, Asn94Ser, in the product of parC . Levofloxacin with reserpine was highly specific for efflux screening.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00107-07

Reference21 articles.

1. Appelbaum, P. C. 2002. Resistance among Streptococcus pneumoniae: implications for drug selection. Clin. Infect. Dis.34:1613-1620.

2. Broskey, J., K. Coleman, M. N. Gwynn, L. McCloskey, C. Traini, L. Voelker, et al. 2000. Efflux and target mutations as quinolone resistance mechanisms in clinical isolates of Streptococcus pneumoniae. J. Antimicrob. Chemother.45(Suppl. 1):95-99.

3. Prevalence and Molecular Analysis of Macrolide and Fluoroquinolone Resistance among Isolates of Streptococcus pneumoniae Collected during the 2000-2001 PROTEKT US Study

4. Canton, R., M. Morosini, M. C. Enright, and I. Morrissey. 2003. Worldwide incidence, molecular epidemiology and mutations implicated in fluoroquinolone-resistant Streptococcus pneumoniae: data from the global PROTEKT surveillance programme. J. Antimicrob. Chemother.52:944-952.

5. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically 2006

Cited by 16 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Resistance to Empirical Antibiotics among Pathogens Causing Community-Acquired Pneumonia in Korea;Journal of Korean Society of Health-System Pharmacists;2017-11

2. Multidrug-Resistant Gram-Positive Bacterial Infections;Korean Journal of Medicine;2015

3. A 2011-2012 Survey of Doctors' Perceptions of Korean Guidelines and Empirical Treatment of Community-Acquired Pneumonia;Infection & Chemotherapy;2013

4. Antibiotic Development;Pharmaceutical Sciences Encyclopedia;2011-12-16

5. Serotype distribution and antibiotic resistance of 140 pneumococcal isolates from pediatric patients with upper respiratory infections in Beijing, 2010;Vaccine;2011-10