Affiliation:
1. Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
Abstract
SUMMARY
Three-quarters of a century after the introduction of
Mycobacterium bovis
BCG, the first tuberculosis vaccine, new vaccines for tuberculosis are finally entering clinical trials. This breakthrough is based not only on advances in proteomics and genomics which have made the construction of new vaccines possible, but also on a greatly expanded knowledge of the immunology of tuberculosis. Here we review our current understanding of how
Mycobacterium tuberculosis
subverts or survives the host's immune response to cause disease and why the current vaccination strategy, which relies on BCG, is only partially successful in countering the pathogen. This provides a background for describing the new generation of vaccines designed to supplement or replace the current vaccine and the different approaches they take to stimulate immunity against
M. tuberculosis
.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology
Reference195 articles.
1. Aaron, L., D. Saadoun, I. Calatroni, O. Launay, N. Memain, V. Vincent, G. Marchal, B. Dupont, O. Bouchaud, D. Valeyre, and O. Lortholary. 2004. Tuberculosis in HIV-infected patients: a comprehensive review. Clin. Microbiol. Infect.10:388-398.
2. Tuberculosis subunit vaccine development: on the role of interferon-γ
3. Anonymous 1999. Fifteen year follow up of trial of BCG vaccines in south India for tuberculosis prevention. Indian J. Med. Res.110:56-69.
4. Anonymous 2005. Global tuberculosis control - surveillance planning financing W.H.O./HTM/TB/2005. World Health Organization Geneva Switzerland.
5. Arias, M., M. Rojas, J. Zabaleta, J. I. Rodriguez, S. C. Paris, L. F. Barrera, and L. F. Garcia. 1997. Inhibition of virulent Mycobacterium tuberculosis by Bcg(r) and Bcg(s) macrophages correlates with nitric oxide production. J Infect. Dis.176:1552-1558.
Cited by
81 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献