Understanding Hepatitis B Virus Dynamics and the Antiviral Effect of Interferon Alpha Treatment in Humanized Chimeric Mice

Author:

Reinharz Vladimir1,Ishida Yuji23,Tsuge Masataka245,Durso-Cain Karina467,Chung Tje Lin48,Tateno Chise23,Perelson Alan S.9ORCID,Uprichard Susan L.467ORCID,Chayama Kazuaki21011,Dahari Harel4ORCID

Affiliation:

1. Department of Computer Science, Université du Québec à Montréal, Montreal, Quebec, Canada

2. Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Japan

3. PhoenixBio Co., Ltd., Hiroshima, Japan

4. The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA

5. Natural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan

6. Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Medical Center, Maywood, Illinois, USA

7. Infectious Disease and Immunology Research Institute, Stritch School of Medicine, Loyola University Medical Center, Maywood, Illinois, USA

8. Institut für Biostatistik and Mathematische Modellierung, Fachbereich Medizin, Goethe Universität, Frankfurt, Germany

9. Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, USA

10. Institute of Physical and Chemical Research (RIKEN) Center for Integrative Medical Sciences, Yokohama, Japan

11. Collaborative Research Laboratory of Medical Innovation, Hiroshima University, Hiroshima, Japan

Abstract

Chronic hepatitis B virus (HBV) infection remains a global health care problem, as we lack sufficient curative treatment options. Elucidating the dynamics of HBV infection and treatment response at the molecular level could facilitate the development of novel, more effective HBV antivirals.

Funder

HHS | NIH | OSC | Common Fund

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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