Protection of Mice against Experimental Cryptococcosis by Synthesized Peptides Delivered in Glucan Particles

Author:

Specht Charles A.1,Homan E. Jane2,Lee Chrono K.1,Mou Zhongming1,Gomez Christina L.1,Hester Maureen M.1,Abraham Ambily3,Rus Florentina3,Ostroff Gary R.3,Levitz Stuart M.1

Affiliation:

1. Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA

2. ioGenetics LLC, Madison, Wisconsin, USA

3. Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA

Abstract

Cryptococcosis, due to infection by fungi of theCryptococcus neoformansspecies complex, is responsible for substantial morbidity and mortality in immunocompromised persons, particularly those with AIDS. Cryptococcal vaccines are a public health priority yet are not available for human use.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference48 articles.

1. Cryptococcus

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4. Immunocompromised Hosts: Cryptococcosis in Solid Organ Transplant Recipients: Current State of the Science

5. Wozniak KL, Levitz SM. 2011. T cell and dendritic cell immune responses to Cryptococcus, p 387–396. In Heitman J, Kozel TR, Kwon-Chung JK, Perfect JR, Casadevall A (ed), Cryptococcus: from human pathogen to model yeast. ASM Press, Washington, DC.

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