Escherichia coli Nissle 1917 Enhances Innate and Adaptive Immune Responses in a Ciprofloxacin-Treated Defined-Microbiota Piglet Model of Human Rotavirus Infection

Author:

Michael Husheem1,Paim Francine C.1,Langel Stephanie N.1,Miyazaki Ayako12,Fischer David D.1,Chepngeno Juliet1,Amimo Joshua1,Deblais Loic1,Rajashekara Gireesh1,Saif Linda J.1ORCID,Vlasova Anastasia N.1ORCID

Affiliation:

1. Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA

2. Division of Viral Disease and Epidemiology, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan

Abstract

Rotavirus (RV) is a primary cause of malabsorptive diarrhea in children and is associated with significant morbidity and mortality, especially in developing countries. The use of antibiotics exacerbates intestinal microbial imbalance and results in the persistence of RV-induced diarrhea.

Funder

Federal and State Funds to OARDC, OSU

Bill and Melinda Gates Foundation

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | National Institutes of Health

Office of Dietary Supplements

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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