A Critical Analysis of the Evidence for the SARS-CoV-2 Origin Hypotheses

Author:

Alwine James C.12,Casadevall Arturo3,Enquist Lynn W.24ORCID,Goodrum Felicia D.25ORCID,Imperiale Michael J.6

Affiliation:

1. Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

2. Department of Immunobiology, University of Arizona, Tucson, Arizona, USA

3. Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

4. Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA

5. BIO5 Institute, University of Arizona, Tucson, Arizona, USA

6. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA

Abstract

When humans experience a new, devastating viral infection such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), significant challenges arise. How should individuals as well as societies respond to the situation? One of the primary questions concerns the origin of the SARS-CoV-2 virus that infected and was transmitted efficiently among humans, resulting in a pandemic.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference33 articles.

1. Can Science Help Resolve the Controversy on the Origins of the SARS-CoV-2 Pandemic?

2. WHO. 2021. WHO-convened global study of origins of SARS-CoV-2: China part. WHO, Geneva, Switzerland. https://www.who.int/publications/i/item/who-convened-global-study-of-origins-of-sars-cov-2-china-part. Accessed 5 March 2023.

3. Avoiding culture shock with the SARS-CoV-2 spike protein

4. A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice

5. Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variant

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