Novel Highly Pathogenic Avian A(H5N2) and A(H5N8) Influenza Viruses of Clade 2.3.4.4 from North America Have Limited Capacity for Replication and Transmission in Mammals

Author:

Kaplan Bryan S.1,Russier Marion1,Jeevan Trushar1,Marathe Bindumadhav1,Govorkova Elena A.1,Russell Charles J.1,Kim-Torchetti Mia2,Choi Young Ki3,Brown Ian4,Saito Takehiko5,Stallknecht David E.6,Krauss Scott1,Webby Richard J.1

Affiliation:

1. Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

2. National Veterinary Services Laboratories, Science, Technology and Analysis Services, Veterinary Services, Animal and Plant Health Inspection Service, U.S. Department of Agriculture, Ames, Iowa, USA

3. College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, South Korea

4. Animal and Plant Health Agency, New Haw, Addlestone, Surrey, United Kingdom

5. Influenza and Prion Disease Research Center, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan

6. Department of Population Health, College of Veterinary Medicine, The University of Georgia, Athens, Georgia, USA

Abstract

Highly pathogenic H5 influenza viruses have been introduced into North America from Asia, causing extensive morbidity and mortality in domestic poultry. The introduced viruses have reassorted with North American avian influenza viruses, generating viral genotypes not seen on other continents. The experiments and analyses presented here were designed to assess the impact of this genetic diversification on viral phenotypes, particularly as regards mammalian hosts, by comparing the North American viruses with their Eurasian precursor viruses.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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