Bolaamphiphile Analogues of 12-bis-THA Cl <sub>2</sub> Are Potent Antimicrobial Therapeutics with Distinct Mechanisms of Action against Bacterial, Mycobacterial, and Fungal Pathogens-Reference-Cited by-同舟云学术

Bolaamphiphile Analogues of 12-bis-THA Cl ₂ Are Potent Antimicrobial Therapeutics with Distinct Mechanisms of Action against Bacterial, Mycobacterial, and Fungal Pathogens

Published:2023-02-21 Issue:1 Volume:8 Page:
ISSN:2379-5042
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language:en
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Author:

Di Blasio Simona¹^ORCID,Clarke Maria¹^ORCID,Hind Charlotte K.²,Asai Masanori³⁴,Laurence Louis⁵,Benvenuti Angelica¹,Hassan Mahnoor¹,Semenya Dorothy¹,Man DeDe Kwun-Wai¹⁶,Horrocks Victoria¹,Manzo Giorgia¹,Van Der Lith Sarah¹,Lam Carolyn¹,Gentile Eugenio¹,Annette Callum¹,Bosse Janine³^ORCID,Li Yanwen³,Panaretou Barry¹,Langford Paul R.³^ORCID,Robertson Brian D.⁴,Lam Jenny K. W.⁶⁷,Sutton J. Mark¹²,McArthur Michael⁵,Mason A. James¹^ORCID

Affiliation:

1. Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Sciences, King’s College London, London, United Kingdom

2. Technology Development Group, UK Health Security Agency, Research and Evaluation, Salisbury, United Kingdom

3. Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London, London, United Kingdom

4. MRC Centre for Molecular Bacteriology and Infection, Department of Infectious Disease, Imperial College London, London, United Kingdom

5. Norwich Medical School, University of East Anglia, Norwich, United Kingdom

6. Department of Pharmacology & Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong

7. Department of Pharmaceutics, UCL School of Pharmacy, University College London, London, United Kingdom

Abstract

While we face an acute threat from antibiotic resistant bacteria and a lack of new classes of antibiotic, there are many effective antimicrobials which have limited application due to concerns regarding their toxicity and which could be more useful if such risks are reduced or eliminated. We modified a bolalipid antiseptic used in throat lozenges to see if it could be made more effective against some of the highest-priority bacteria and less toxic.

Funder

National Centre for the Replacement Refinement and Reduction of Animals in Research

UKRI | Biotechnology and Biological Sciences Research Council

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00508-22

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