Stability of SARS-CoV-2 Spike G614 Variant Surpasses That of the D614 Variant after Cold Storage

Author:

Huang Sheng-Yu12ORCID,Kung Yu-An12,Huang Peng-Nien123,Chang Sheng-Yun14,Gong Yu-Nong15ORCID,Han Yi-Ju16,Chiang Huan-Jung12,Liu Kuan-Ting16,Lee Kuo-Ming1ORCID,Chang Chia-Yu78,Chang Chia-Ching78910,Huang Chung-Guei25,Shih Shin-Ru1251112ORCID

Affiliation:

1. Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan

2. Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan

3. Division of Infectious Diseases, Department of Pediatrics, Linkou Chung Chang Gung Memorial Hospital, Taoyuan, Taiwan

4. Bachelor Program in Artificial Intelligence, College of Engineering, Chang Gung University, Taoyuan, Taiwan

5. Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan

6. Graduate Institute of Biomedical Science, Division of Biotechnology, College of Medicine, Chang Gung University, Taoyuan, Taiwan

7. Department of Biological Science and Technology, College of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan

8. Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, Taiwan

9. Department of Electrophysics, National Yang Ming Chiao Tung University, Hsinchu, Taiwan

10. Institute of Physics, Academia Sinica, Nankang, Taipei, Taiwan

11. Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Taoyuan, Taiwan

12. Research Center for Food and Cosmetic Safety, Chang Gung University of Science and Technology, Taoyuan, Taiwan

Abstract

It has been observed that variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more stable and infectious after storage at −20°C than at 4°C. A SARS-CoV-2 S-D614G variant is currently the most dominant variant in circulation and is associated with enhanced infectivity.

Funder

Chang Gung Memorial Hospital

Ministry of Science and Technology, Taiwan

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference27 articles.

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2. Johns Hopkins University of Medicine. 2020. Mortality analyses. Coronavirus Resource Center Johns Hopkins University of Medicine Baltimore MD. https://coronavirus.jhu.edu/data/mortality. Accessed 29 December 2020.

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