Andes Virus Genome Mutations That Are Likely Associated with Animal Model Attenuation and Human Person-to-Person Transmission

Author:

Bellomo Carla M.1ORCID,Alonso Daniel O.1ORCID,Pérez-Sautu Unai2,Prieto Karla23,Kehl Sebastian1ORCID,Coelho Rocio M.1ORCID,Periolo Natalia1ORCID,Di Paola Nicholas2ORCID,Ferressini-Gerpe Natalia4,Kuhn Jens H.5ORCID,Sanchez-Lockhart Mariano2,Palacios Gustavo46ORCID,Martínez Valeria P.1ORCID

Affiliation:

1. Laboratorio Nacional de Referencia de Hantavirus, Instituto Nacional de Enfermedades Infecciosas, Administración Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbran, Buenos Aires, Argentina

2. Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA

3. College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska, USA

4. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

5. Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA

6. Global Health Emerging Pathogen Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Abstract

Several orthohantaviruses cause the zoonotic disease hantavirus pulmonary syndrome (HPS) in the Americas. Among them, HPS caused by Andes virus (ANDV) is of great public health concern because it is associated with the highest case fatality rate (up to 50%).

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference51 articles.

1. Kuhn JH, Charrel RN. 2018. Arthropod-borne and rodent-borne virus infections, p 1489–1509. In Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J (ed), Harrison's principles of internal medicine, 20th ed, vol 2. McGraw-Hill Education, Columbus, OH.

2. Epidemiological description, case‐fatality rate, and trends of Hantavirus Pulmonary Syndrome: 9 years of surveillance in Argentina

3. Hantavirus Pulmonary Syndrome in Argentina, 1995–2008

4. An Unusual Hantavirus Outbreak in Southern Argentina: Person-to-Person Transmission?

5. Factores pronósticos de síndrome cardiopulmonar y muerte por hantavirus Andes Sur: estudio de cohorte en San Carlos de Bariloche y su zona de influencia sanitaria;Tortosa F;Medicina (B Aires),2022

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