Vaccine-Induced, High-Magnitude HIV Env-Specific Antibodies with Fc-Mediated Effector Functions Are Insufficient to Protect Infant Rhesus Macaques against Oral SHIV Infection

Author:

Curtis Alan D.123,Saha Pooja T.4ORCID,Dennis Maria5,Berendam Stella J.5,Ramasubramanian Pratamesh6,Cross Kaitlyn A.4,Alam S. Munir5ORCID,Ferrari Guido567,Kozlowski Pamela A.8,Fouda Genevieve G.5ORCID,Hudgens Michael G.4,Van Rompay Koen K. A.9ORCID,Pollara Justin567,Permar Sallie R.10,De Paris Kristina123ORCID

Affiliation:

1. Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

2. Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

3. Children’s Research Institute, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

4. Department of Biostatistics, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

5. Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA

6. Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA

7. Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA

8. Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA

9. California National Primate Research Center, University of California at Davis, Davis, California, USA

10. Department of Pediatrics, Weill Cornell Medical College, New York, New York, USA

Abstract

Women of childbearing age are three times more likely to contract HIV infection than their male counterparts. Poor HIV testing rates coupled with low adherence to antiretroviral therapy (ART) result in a high risk of mother-to-infant HIV transmission, especially during the breastfeeding period.

Funder

National Institute of Allergy and Infectious Diseases

Center for AIDS Research, University of North Carolina at Chapel HIll

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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