Relative Dominance of Gag p24-Specific Cytotoxic T Lymphocytes Is Associated with Human Immunodeficiency Virus Control-Reference-Cited by-同舟云学术

Relative Dominance of Gag p24-Specific Cytotoxic T Lymphocytes Is Associated with Human Immunodeficiency Virus Control

Published:2006-03-15 Issue:6 Volume:80 Page:3122-3125
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Zuñiga Rosario¹,Lucchetti Aldo¹,Galvan Patricia¹,Sanchez Shyla¹,Sanchez Carmen¹,Hernandez Ana¹,Sanchez Hugo¹,Frahm Nicole²,Linde Caitlyn H.²,Hewitt Hannah S.²,Hildebrand William³,Altfeld Marcus²,Allen Todd M.²,Walker Bruce D.²,Korber Bette T.⁴,Leitner Thomas⁴,Sanchez Jorge¹,Brander Christian²

Affiliation:

1. Asociación Civil IMPACTA Salud y Educación, Lima, Peru

2. Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts

3. University of Oklahoma, Norman, Oklahoma

4. Los Alamos National Laboratory, Los Alamos, and Santa Fe Institute, Santa Fe, New Mexico

Abstract

ABSTRACT Conflicting data on the role of total virus- and protein-specific cytotoxic-T-lymphocyte (CTL) responses in the control of human immunodeficiency virus (HIV) disease progression exist. We present data generated from a Peruvian cohort of untreated, clade B-infected subjects, demonstrating that the proportion of Gag-specific, and in particular p24-reactive, CTL responses among the total virus-specific CTL activity is associated with individuals' CD4 counts and viral loads. Analyses in a second cohort in the United States confirm these findings and point towards a dominant role of Gag-specific immunity in effective control of HIV infection, providing important guidance for HIV vaccine development.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.80.6.3122-3125.2006

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