Impact of Salmonella Infection on Host Hormone Metabolism Revealed by Metabolomics

Author:

Antunes L. Caetano M.1,Arena Ellen T.12,Menendez Alfredo1,Han Jun3,Ferreira Rosana B. R.1,Buckner Michelle M. C.12,Lolić Petra12,Madilao Lufiani L.1,Bohlmann Jörg1,Borchers Christoph H.3,Finlay B. Brett12

Affiliation:

1. Michael Smith Laboratories, The University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

2. Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada

3. University of Victoria—Genome BC Proteomics Centre, University of Victoria, Victoria, British Columbia V8Z 7X8, Canada

Abstract

ABSTRACT The interplay between pathogens and their hosts has been studied for decades using targeted approaches, such as the analysis of mutants and host immunological responses. Although much has been learned from such studies, they focus on individual pathways and fail to reveal the global effects of infection on the host. To alleviate this issue, high-throughput methods, such as transcriptomics and proteomics, have been used to study host-pathogen interactions. Recently, metabolomics was established as a new method to study changes in the biochemical composition of host tissues. We report a metabolomic study of Salmonella enterica serovar Typhimurium infection. Our results revealed that dozens of host metabolic pathways are affected by Salmonella in a murine infection model. In particular, multiple host hormone pathways are disrupted. Our results identify unappreciated effects of infection on host metabolism and shed light on mechanisms used by Salmonella to cause disease and by the host to counter infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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