Viral Respiratory Pathogens and Lung Injury

Author:

Clementi Nicola12ORCID,Ghosh Sreya3,De Santis Maria4,Castelli Matteo1,Criscuolo Elena1,Zanoni Ivan35,Clementi Massimo12,Mancini Nicasio12ORCID

Affiliation:

1. Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, Milan, Italy

2. Laboratory of Microbiology and Virology, IRCCS San Raffaele Scientific Institute, Milan, Italy

3. Harvard Medical School, Boston Children’s Hospital, Division of Immunology, Boston, Massachusetts, USA

4. Department of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center–IRCCS, Rozzano, Italy

5. Harvard Medical School, Boston Children’s Hospital, Division of Gastroenterology, Boston, Massachusetts, USA

Abstract

Several viruses target the human respiratory tract, causing different clinical manifestations spanning from mild upper airway involvement to life-threatening acute respiratory distress syndrome (ARDS). As dramatically evident in the ongoing SARS-CoV-2 pandemic, the clinical picture is not always easily predictable due to the combined effect of direct viral and indirect patient-specific immune-mediated damage.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

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