Distinct Regulations of HO-1 Gene Expression for Stress Response and Substrate Induction-Reference-Cited by-同舟云学术

Distinct Regulations of HO-1 Gene Expression for Stress Response and Substrate Induction

Published:2021-10-26 Issue:11 Volume:41 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Zhang Anqi¹,Suzuki Takafumi¹,Adachi Saki¹,Naganuma Eriko¹,Suzuki Norio²,Hosoya Tomonori³,Itoh Ken³,Sporn Michael B.⁴,Yamamoto Masayuki¹⁵⁶^ORCID

Affiliation:

1. Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan

2. Division of Oxygen Biology, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

3. Department of Stress Response Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

4. Molecular and Systems Biology, Dartmouth Medical School, Lebanon, New Hampshire, USA

5. Tohoku Medical-Megabank Organization, Sendai, Japan

6. The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan

Abstract

Heme oxygenase-1 (HO-1) is the key enzyme for heme catabolism and cytoprotection. Whereas HO-1 gene expression in response to various stresses has been investigated extensively, the precise mechanisms by which HO-1 gene expression is regulated by the HO-1 substrate heme remain elusive. To systematically examine whether stress-mediated induction and substrate-mediated induction of HO-1 utilize similar or distinct regulatory pathways, we developed an HO-1–DsRed-knock-in reporter mouse in which the HO-1 gene is floxed by loxP sites and the DsRed gene has been inserted.

Funder

Japan Agency for Medical Research and Development

MEXT | Japan Society for the Promotion of Science

Takeda Science Foundation

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00236-21

Reference62 articles.

1. Heme oxygenase and heme degradation