Contemporary Prevalence of BRO β-Lactamases in Moraxella catarrhalis : Report from the SENTRY Antimicrobial Surveillance Program (North America, 1997 to 2004)

Author:

Deshpande Lalitagauri M.1,Sader Helio S.1,Fritsche Thomas R.1,Jones Ronald N.12

Affiliation:

1. JMI Laboratories, North Liberty, Iowa

2. Tufts University School of Medicine, Boston, Massachusetts

Abstract

ABSTRACT A total of 7,860 community-acquired Moraxella catarrhalis isolates (SENTRY Antimicrobial Surveillance Program, 1997 to 2004) were tested by broth microdilution methods, and 399 randomly selected strains from North American sites were tested for BRO-1 and BRO-2 by PCR methods. Several antimicrobials remained very active, including amoxicillin-clavulanate (MIC 90 s, ≤0.25 μg/ml), azithromycin (MIC 90 s, ≤0.12 μg/ml), ceftriaxone (MIC 90 s, 0.5 μg/ml), and levofloxacin (MIC 90 s, ≤0.03 to 0.06 μg/ml). The BRO-2 incidence rates by year were 3 to 4% overall (96 to 97% for BRO-1) and were the highest in Canada (7.9%), with the incidence in the United States being only 2.0%.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference16 articles.

1. Moraxella (Branhamella)catarrhalis BRO β-Lactamase: a Lipoprotein of Gram-Positive Origin?

2. Bootsma, H. J., H. van Dijk, P. Vauterin, J. Verhoef, and F. R. Mooi. 2000. Genesis of BRO beta-lactamase-producing Moraxella catarrhalis: evidence for transformation-mediated horizontal transfer. Mol. Microbiol.36:93-104.

3. Molecular characterization of the BRO beta-lactamase of Moraxella (Branhamella) catarrhalis

4. Clinical and Laboratory Standards Institute. 2006. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Document M7-A7. Clinical and Laboratory Standards Institute Wayne Pa.

5. Clinical and Laboratory Standards Institute. 2006. Performance standards for antimicrobial disk susceptibility tests 9th ed. Approved standard M2-A9. Clinical and Laboratory Standards Institute Wayne Pa.

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