Hyperglycemia Increases Severity of Staphylococcus aureus Osteomyelitis and Influences Bacterial Genes Required for Survival in Bone-Reference-Cited by-同舟云学术

Hyperglycemia Increases Severity of Staphylococcus aureus Osteomyelitis and Influences Bacterial Genes Required for Survival in Bone

Published:2023-04-18 Issue:4 Volume:91 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Butrico Casey E.¹,Klopfenstein Nathan¹,Green Erin R.¹,Johnson Joshua R.²³,Peck Sun H.²³⁴⁵,Ibberson Carolyn B.⁶,Serezani C. Henrique¹⁷⁸,Cassat James E.¹²⁵⁸⁹^ORCID

Affiliation:

1. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

2. Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

3. Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA

4. Nashville VA Medical Center, Department of Veterans Affairs, Nashville, Tennessee, USA

5. Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA

6. Department of Microbiology and Plant Biology, The University of Oklahoma, Norman, Oklahoma, USA

7. Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA

8. Vanderbilt Institute for Infection, Immunology, and Inflammation (VI4), Vanderbilt University Medical Center, Nashville, Tennessee, USA

9. Department of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Abstract

Hyperglycemia, or elevated blood glucose, renders individuals more prone to developing severe Staphylococcus aureus infections. S. aureus is the most common etiological agent of musculoskeletal infection, which is a common manifestation of disease in hyperglycemic patients. However, the mechanisms by which S. aureus causes severe musculoskeletal infection during hyperglycemia are incompletely characterized.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Veterans Affairs

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Burroughs Wellcome Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00529-22