Affiliation:
1. Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, Kentucky 40292
Abstract
ABSTRACT
The
Nkx
homeobox genes are expressed in a variety of developing tissues and have been implicated in controlling tissue patterning and cell differentiation. Expression of
Nkx6.2
(
Gtx
) was previously observed in the embryonic neural tube, testis, and differentiating oligodendrocytes. To investigate the role of
Nkx6.2
in the control of cell specification and differentiation, we generated mice with null mutations in
Nkx6.2
using the standard gene targeting approach. Null mutant mice were viable and fertile without apparent histological and immunohistochemical changes in the central nervous systems and testis. The absence of detectable phenotypes suggests a redundant function of
Nkx6.2
in mouse development.
Publisher
American Society for Microbiology
Subject
Cell Biology,Molecular Biology
Cited by
24 articles.
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